GB Virus C/Hepatitis G Virus Envelope Glycoprotein E2: Computational Molecular Features and Immunoinformatics Study
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چکیده
منابع مشابه
gb virus c/hepatitis g virus envelope glycoprotein e2: computational molecular features and immunoinformatics study
conclusions the comprehensive analysis of a protein with important roles has never been easy, and in case of e2 envelope glycoprotein of hgv, there is no much data on its molecular and immunological features, clinical significance and its pathogenic potential in hepatitis or any other gbv-c related diseases. so, results of the present study may explain some structural, physiological and immunol...
متن کاملGB Virus C/Hepatitis G Virus Envelope Glycoprotein E2: Computational Molecular Features and Immunoinformatics Study
INTRODUCTION GB virus C (GBV-C) or hepatitis G virus (HGV) is an enveloped, RNA positive-stranded flavivirus-like particle. E2 envelope protein of GBV-C plays an important role in virus entry into the cytosol, genotyping and as a marker for diagnosing GBV-C infections. Also, there is discussion on relations between E2 protein and gp41 protein of HIV. The purposes of our study are to multi aspec...
متن کاملIdentification of Aptamer-Binding Sites in Hepatitis C Virus Envelope Glycoprotein E2
Hepatitis C Virus (HCV) encodes two envelope glycoproteins, E1 and E2. Our previous work selected a specific aptamer ZE2, which could bind to E2 with high affinity, with a great potential for developing new molecular probes as an early diagnostic reagents or therapeutic drugs targeting HCV. In this study, the binding sites between E2 and aptamer ZE2 were further explored. E2 was truncated to 15...
متن کاملMolecular links between the E2 envelope glycoprotein and nucleocapsid core in Sindbis virus.
A three-dimensional reconstruction of Sindbis virus at 7.0 Å resolution presented here provides a detailed view of the virion structure and includes structural evidence for key interactions that occur between the capsid protein (CP) and transmembrane (TM) glycoproteins E1 and E2. Based on crystal structures of component proteins and homology modeling, we constructed a nearly complete, pseudo-at...
متن کاملGB virus-C (hepatitis G virus) nostalgia.
The newly discovered human flavivirus identified as GB virus-C [1] and hepatitis G virus (HGV) [2], presents intriguing challenges in virology, epidemiology, and blood banking. Its clinical relevance for hepatology, however, appears to have been short-lived. Murthy and colleagues in this issue of Kidney International [3] provide additional evidence that the virus is not associated with clinical...
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ژورنال
عنوان ژورنال: Hepatitis Monthly
سال: 2013
ISSN: 1735-143X,1735-3408
DOI: 10.5812/hepatmon.15342